A New Hope for Breast Cancer Patients
Millions of breast cancer patients could soon avoid the physical and emotional burden of chemotherapy thanks to a groundbreaking gene test. This innovative approach, known as Prosigna, measures the activity of genes involved in breast cancer growth. A recent study involving over 4,400 patients aged 40 and over across several countries found that chemotherapy had “little or no additional benefit” for those with low Prosigna scores.
The Study and Its Implications
The trial, led by University College London (UCL), aimed to determine if this method would lead to a meaningful increase in the number of patients whose cancer returned or died within five years. The results showed that more than two-thirds of participants could be safely treated with hormone therapy alone, avoiding the need for chemotherapy.
Mother-of-two Karen Bonham, from Cardiff, who took part in the international clinical trial, described receiving the news she did not need the treatment as feeling “like Christmas.” After being diagnosed with breast cancer following a routine screening in June 2017, Ms. Bonham was initially dreading the prospect of chemotherapy.
She said: “Cancer diagnosis and treatment can be shocking. It certainly propels you into a world of uncertainty.”
Life priorities realign – you simply want to survive. Life certainly becomes busy – a whirlwind of appointments, information and rapid decision-making. All while trying to keep a sense of normalcy for your family, especially when children may be confronting GCSEs, uni finals.
Ms. Bonham, who worked as a speech and language therapist for four decades, agreed to take part in the trial in the hope that she could avoid chemotherapy. The 64-year-old had already cut her hair short when she got the news she would not require the treatment, while walking on a beach.
Ms. Bonham said: “How to describe the initial feeling? Immense relief? Like Christmas? Certainly a mixture of the two.”
Instead of chemotherapy, she received radiotherapy and hormone therapy, and completed eight years of active treatment. Almost nine years on from her diagnosis, Ms. Bonham said she does not feel defined by cancer, has returned to normal family life, and enjoys keeping active, walking and yoga.
Benefits of Hormone Therapy
Regularly offered to people with early-stage breast cancer that has spread to the nearby lymph nodes, chemotherapy lowers the risk of it returning. But it comes with significant side effects and clinicians are concerned it offers little benefit to those with the most common, hormone-sensitive type of breast cancer, UCL said.
The university said researchers estimate more than 5,000 NHS patients a year could avoid chemotherapy thanks to the trial. The trial’s chief investigator, and professor of breast oncology at the UCL Cancer Institute, Professor Rob Stein, said:
“These results mark an important and significant step toward more personalised treatment. The trial has successfully used tumour biology to guide decisions rather than relying solely on traditional clinical features. For patients, this means many may be spared the physical and emotional burden of chemotherapy and its potential long-term side effects. For health systems, it represents a more efficient and evidence-based use of resources.”
Future Research and Considerations
It is not known whether the findings apply to people under the age of 40, UCL said. It is hoped that more information about the use of the gene test for pre-menopausal women will emerge in the next phase of the trial, but a result is “still several years away,” the university added.
