Heart Disease Death Rates in the United States
A recent analysis has highlighted the stark regional disparities in heart disease death rates across the United States, with Southern states experiencing significantly higher mortality compared to other regions. The study, conducted by healthcare company NiceRx using data from the Centers for Disease Control and Prevention (CDC), revealed that Oklahoma has the highest rate of heart disease deaths in the country, while Minnesota has the lowest.
Heart disease remains the leading cause of death in the US, claiming nearly 700,000 lives annually—approximately one person every 34 seconds. Nationally, the death rate stands at 201 per 100,000 people each year. However, in Oklahoma, this rate jumps to 251 per 100,000, which is almost 25% above the national average.
Seven out of the ten states with the highest heart disease death rates are located in the South, including Mississippi, Alabama, Arkansas, Louisiana, Tennessee, and West Virginia. In contrast, Western states generally report the lowest rates. Minnesota leads the list with a death rate of 120 per 100,000 people, followed closely by Hawaii and Colorado.
Heart disease encompasses a range of conditions affecting the heart, with coronary artery disease being the most common. This condition involves the buildup of fatty deposits in blood vessels, which can restrict blood flow and increase the risk of heart attacks and strokes.
Experts have noted that the disparity in heart disease mortality aligns with obesity rates across the country. States with higher obesity levels also tend to have higher rates of high blood pressure, high cholesterol, and type 2 diabetes—key risk factors for heart disease.
Rob Stransky, president of NiceRx, emphasized that heart disease places a significant burden on the US population, but its impact is not evenly distributed. He explained that carrying excess weight increases the risk of various health issues that strain the heart over time, potentially leading to serious complications such as heart attacks and strokes.
Lifestyle and healthcare differences between regions also play a role in these disparities. People in Southern states are more likely to consume fried and fast foods, increasing their risk of obesity, while also being less likely to have health insurance, which can delay diagnosis and treatment of heart disease.

On the other hand, individuals in Western states often adopt healthier lifestyles, consuming more whole and minimally processed foods, exercising more frequently, and having better access to healthcare. This may contribute to lower heart disease death rates in these regions.
Oklahoma rounds out the top five states with the highest heart disease death rates, alongside Mississippi, Alabama, Arkansas, and Louisiana. Each of these states recorded at least 217 heart disease deaths per 100,000 people annually. Meanwhile, Massachusetts and Connecticut joined Minnesota in the group with the lowest rates, recording 129 and 130 deaths per 100,000 people respectively.
The reasons behind Oklahoma’s high death rate remain unclear, though the state has the 14th highest obesity rate nationwide and the third highest proportion of residents without health insurance. Similarly, Minnesota’s strong performance is not fully understood, but experts suggest it may be linked to better healthcare coverage and lower obesity and smoking rates.
The report also examined changes in heart disease death rates over the past decade, comparing 2023 figures with those from ten years earlier. New Mexico experienced the sharpest increase, with a 13.7% rise in heart disease deaths despite ranking 21st overall. Iowa saw the second-fastest increase at 12.1%, followed by Nebraska at 11%.
Conversely, 28 states reported declines in heart disease deaths during the same period. New York had the steepest drop, with a 14.3% decrease, followed by New Jersey at 12.1% and Connecticut at 10.9%. New Mexico also saw the fastest rise in obesity rates over the decade, with a 33.7% increase.
In the tri-state area covering New York, New Jersey, and Connecticut, obesity rates stopped rising in 2024, according to the latest data. Stransky added that losing weight can be challenging for many individuals, particularly those who have struggled with diet and exercise alone. Sustainable lifestyle changes, such as eating a balanced diet, staying active, reducing processed foods, and improving sleep, remain essential. For some, medically guided weight loss support can also be beneficial.






