Texas Launches Independent Research Program on Ibogaine
Texas is taking a bold step in the field of psychedelic research by launching its own program to explore the potential of ibogaine. This move comes after state officials were unable to find a company willing to help develop ibogaine into a drug for FDA approval. Lt. Gov. Dan Patrick and House Speaker Dustin Burrows announced on March 31 that Texas will use $50 million from the Legislature’s investment last year, partnering with statewide medical researchers to proceed with its own ibogaine research program. The lawmakers indicated that multiple proposals from drug companies did not meet the standards for state funds.
“We intend to fully fund this program,” the statement said. This initiative will also receive a federal boost, as President Donald Trump signed an executive order on April 18 to facilitate research into psychedelic drugs—including ibogaine—as a way to treat serious mental health illnesses. The order includes at least $50 million to support investments from states like Texas on this issue.
Katharine Neill Harris, a drug policy fellow at Rice University’s Baker Institute for Public Policy, explained that she wasn’t surprised the state couldn’t attract any companies to join in on ibogaine research. Texas lawmakers set high standards for eligibility for the $50 million state investment. Companies had to provide a plan to get FDA approval to develop ibogaine into a drug, create a corporate presence in Texas, match the $50 million, and commit to Texas 20% of revenue from future sales of the drug after FDA approval.
“That may be seen as a demanding set of conditions in a research area that carries substantial risk, so it is believable that prospective applicants did not meet the requirements,” Harris said.
For several years, people have traveled to clinics in Mexico to take ibogaine. The extract of an ancient African shrub, ibogaine has been used to alleviate addiction and brain trauma. Although it is an illegal drug, Republicans have championed it due to its positive impact on people suffering from PTSD.
Gov. Greg Abbott signed Senate Bill 2308 into law last year, creating a consortium of universities, hospitals, and drug developers to conduct clinical trials of an ibogaine drug and get it approved by the FDA for future sale. Lawmakers approved $50 million in taxpayer dollars to support this effort, making Texas a leader in psychedelic research investment.
Getting drug companies on board was key to making this consortium work because they have the experience of developing a drug that gets FDA approval.
The Texas Tribune asked Patrick, Burrows, and the Texas Health and Human Services Commission why companies didn’t qualify to partner with the state and what next steps will involve. They did not provide answers by the story’s deadline.
Bryan Hubbard, chief executive officer of Americans for Ibogaine, said research institutions across the country are conducting hundreds of clinical trials every day, but what sets Texas apart is its goal of developing ibogaine into an FDA-approved drug that can be sold.
“As we speak, we are seeing bills passed in Mississippi, West Virginia, Oklahoma, Tennessee and Missouri that would join these states together in researching ibogaine, something far more significant than one private developer,” he said. “Texas is what makes this joiner possible.”
Under SB 2308, a public university will manage ibogaine clinical trials in partnership with a drug company and a hospital.
Harris said if the state plans to move forward without a drug company, the state might need to make some legislative or legal fixes to meet the statutory requirements of SB 2308, especially since the bill involves state funding.
“As SB 2308 is written, HHSC should not be able to release the $50 million in state funds to the consortium without the private match,” she said.
Last year, Texas Health and Human Services selected UTHealth Houston, in collaboration with The University of Texas Medical Branch at Galveston, to lead a statewide partnership with other universities to conduct a two-year research trial evaluating the effect of ibogaine on patients with addiction, traumatic brain injury, and other behavioral health conditions.
“This landmark clinical trial reflects our unwavering commitment to advancing research that improves lives and delivers the highest standards of care,” said Melina Kibbe, MD, UTHealth Houston president, in a news release at the time.
Harris said the state’s research institutions are capable of managing clinical trials. She said it’s less clear whether the state is willing and able to fully fund the path to FDA approval without private partners.
“A drug development effort like this will likely require much more than $100 million overall, not just the initial $50 million in state funding,” she said.
Key Points About Texas’ Ibogaine Research Program
- Funding: Texas has allocated $50 million for the research program, aiming to develop ibogaine into an FDA-approved drug.
- Partnerships: The state is working with medical researchers and institutions, including UTHealth Houston and The University of Texas Medical Branch at Galveston.
- Challenges: Finding a private company to partner with has proven difficult, leading the state to consider alternative approaches.
- Federal Support: An executive order from President Trump provides additional funding and support for psychedelic research, including ibogaine.
- Legal Framework: Senate Bill 2308 outlines the framework for the research, requiring a private match for state funds.
- Future Prospects: While the state’s institutions are capable of managing trials, the long-term success of the program depends on securing additional funding and partnerships.
